Article

Epigenetic engineering of yeast reveals dynamic molecular adaptation to methylation stress and genetic modulators of specific DNMT3 family members

2020-01-26

Abstract excerpt

<h4>ABSTRACT</h4> Cytosine methylation is a ubiquitous modification in mammalian DNA generated and maintained by several DNA methyltransferases (DNMTs) with partially overlapping functions and genomic targets. To systematically dissect the factors specifying each DNMT’s activity, we engineered combinatorial knock-in of human DNMT genes in Komagataella phaffii , a yeast species lacking endogenous DNA methylation....

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Literature Corpus work: f2546eaa-7a8f-549a-b627-97ec0cae20ff
DOI: 10.1101/2020.01.26.919936

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