Article
Regulation of glutathione S-transferase Ya subunit gene expression: identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds.
Proceedings of the National Academy of Sciences of the United States of America - 1 May 1990
Rushmore T H, King R G, Paulson K E, Pickett C B
Abstract excerpt
We have identified a region in the 5' flanking sequence of the glutathione S-transferase (RX:glutathione R-transferase, EC 2.5.1.18) Ya subunit gene that contains a unique xenobiotic-responsive element (XRE). The regulatory region spans nucleotides -722 to -682 of the 5' flanking sequence and is...
Topics
- Base Sequence
- Benzoflavones
- Carcinoma, Hepatocellular
- Cell Line
- Cell Nucleus
- Chromosome Deletion
- Cloning, Molecular
- Flavonoids
- Gene Expression Regulation, Enzymologic
- Genes
- Genes, Regulator
- Glutathione Transferase
- Humans
- Liver Neoplasms