Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Xenobiotic-responsive element for the transcriptional activation of the rat Cu/Zn superoxide dismutase gene.

Biochemical and biophysical research communications - 5 Mar 1999

Yoo H Y, Chang M S, Rho H M

Abstract excerpt

Cu/Zn superoxide dismutase (SOD1) catalyzes the dismutation of superoxide radicals produced from biological oxidation and environmental stresses. A number of xenobiotics are toxic because they generate free radicals, such as superoxide and hydroxyl radicals, through a redox cycle. The xenobiotic responsive element (XRE) was located between the nt -268 and -262 region of the 5'-flanking sequence of the SOD1 gene....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Extracts
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Oligonucleotides

Share to Receptors, Aryl Hydrocarbon

Share to Response Elements

Share to Superoxide Dismutase

Share to Transcriptional Activation

Share to Xenobiotics

Source

Identifiers

PMID: 10066436
DOI: 10.1006/bbrc.1999.0299

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Xenobiotic-responsive element for the transcriptional activation of the rat Cu/Zn superoxide dismutase gene.PMID 10066436Read ↗

The transcriptional activation of the human copper/zinc superoxide dismutase gene by 2,3,7,8-tetrachlorodibenzo-p-dioxin through two different regulator sites, the antioxidant responsive element and xenobiotic responsive element.Semantic proximity Read ↗

Transcriptional regulation of thioredoxin reductase 1 expression by cadmium in vascular endothelial cells: role of NF-E2-related factor-2.Semantic proximity Read ↗

Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants.Semantic proximity Read ↗

The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity.Semantic proximity Read ↗

Regulation of glutathione S-transferase Ya subunit gene expression: identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds.Semantic proximity Read ↗

A novel promoter element containing multiple overlapping xenobiotic and hypoxia response elements mediates induction of cytochrome P4502S1 by both dioxin and hypoxia.Semantic proximity Read ↗

Regulation of CYP2A5 gene by the transcription factor nuclear factor (erythroid-derived 2)-like 2.Semantic proximity Read ↗

C-terminal deletion mutant of MRE-binding transcription factor-1 inhibits MRE-driven gene expression.Semantic proximity Read ↗

Cross-talk between xenobiotic detoxication and other signalling pathways: clinical and toxicological consequencesSemantic proximity Read ↗

Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression.Semantic proximity Read ↗

The antioxidant/electrophile response element motif.Semantic proximity Read ↗

Xenobiotic responsive element in the 5'-upstream region of the human P-450c gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.