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Article

Differential LEF1 and TCF4 expression is involved in melanoma cell phenotype switching.

Pigment cell & melanoma research - 1 Aug 2011

Eichhoff Ossia M, Weeraratna Ashani, Zipser Marie C, Denat Laurence, Widmer Daniel S, Xu Mai, Kriegl Lydia, Kirchner Thomas, Larue Lionel, Dummer Reinhard, Hoek Keith S

Abstract excerpt

Recent observations suggest that melanoma cells drive disease progression by switching back and forth between phenotypic states of proliferation and invasion. Phenotype switching has been linked to changes in Wnt signalling, and we therefore looked for cell phenotype-specific differences in the levels and activity of β-catenin and its LEF/TCF co-factors. We found that while cytosolic β-catenin distribution is...

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Source

Identifiers

PMID: 21599871
DOI: 10.1111/j.1755-148X.2011.00871.x

Genes

TCF4
MITF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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