Article

Loss of CITED1, an MITF regulator, drives a phenotype switch in vitro and can predict clinical outcome in primary melanoma tumours

2014-10-09

Abstract excerpt

CITED1 is a non-DNA binding transcriptional co-regulator whose expression can distinguish the ‘proliferative’ from ‘invasive’ signature in the phenotype-switching model of melanoma. We have found that CITED1 expression is repressed by TGFβ in addition to other ‘proliferative’ signature genes while the ‘invasive’ signature genes are upregulated. In agreement, CITED1 positively correlates with MITF expression and c...

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Literature Corpus work: 1c0aadff-ed03-5b33-a7da-3588763a3e77
DOI: 10.7287/peerj.preprints.516v2

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