Article
The Wnts of change: How Wnts regulate phenotype switching in melanoma.
Biochimica et biophysica acta - 1 Dec 2015
Webster Marie R, Kugel Curtis H, Weeraratna Ashani T
Abstract excerpt
The outgrowth of metastatic and therapy-resistant subpopulations in cancer remains a critical barrier for the successful treatment of this disease. In melanoma, invasion and proliferation are uncoupled, such that highly proliferative melanoma cells are less likely to be invasive, and vice versa. The transition between each state is likely a dynamic rather than a static, permanent change. This is referred to as...
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