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Etoposide Metabolites Enhance DNA Topoisomerase II Cleavage near Leukemia-Associated <i>MLL</i> Translocation Breakpoints

12 Jan 2001

Abstract excerpt

Chromosomal breakage resulting from stabilization of DNA topoisomerase II covalent complexes by epipodophyllotoxins may play a role in the genesis of leukemia-associated MLL gene translocations. We investigated whether etoposide catechol and quinone metabolites can damage the MLL breakpoint cluster region in a DNA topoisomerase II-dependent manner like the parent drug and the nature of the damage. Cleavage of two...

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PMID: 11170441
DOI: 10.1021/bi002361x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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