Article
Six-Color Multiplex Digital PCR Assays for Comprehensive Screening and Identification of Multiple Driver Mutations Associated with Pancreatic Carcinogenesis.
Clinical chemistry - 2 Apr 2026
Maeda Chiho, Ono Yusuke, Takahashi Kenji, Mori Miyuki, Suzuki Mayumi, Tamamura Nobue, Sun Yanpeng, Itoh Taito, Tanaka Hiroki, Kawabata Hidemasa, Okada Tetsuhiro, Koyama Kazuya, Ohtaki Yu, Omori Yuko, Yamamoto Takuya, Mizukami Yusuke
Abstract excerpt
BACKGROUND: Digital polymerase chain reaction (dPCR) is widely recognized for its high sensitivity in detecting low-frequency variants; however, conventional 2-color systems have limited multiplex capacity. Expanding this capability is essential for simultaneous detection of multiple driver mutations in cancer-related genes. KRAS and GNAS are key driver genes in the early development of pancreatic cancer and its...
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