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Article

Generation and analyses of R8L barttin knockin mouse.

American journal of physiology. Renal physiology - 1 Aug 2011

Nomura Naohiro, Tajima Masato, Sugawara Noriko, Morimoto Tetsuji, Kondo Yoshiaki, Ohno Mayuko, Uchida Keiko, Mutig Kerim, Bachmann Sebastian, Soleimani Manoocher, Ohta Eriko, Ohta Akihito, Sohara Eisei, Okado Tomokazu, Rai Tatemitsu, Jentsch Thomas J, Sasaki Sei, Uchida Shinichi

Abstract excerpt

Barttin, a gene product of BSND, is one of four genes responsible for Bartter syndrome. Coexpression of barttin with ClC-K chloride channels dramatically induces the expression of ClC-K current via insertion of ClC-K-barttin complexes into plasma membranes. We previously showed that stably expressed R8L barttin, a disease-causing missense mutant, is retained in the endoplasmic reticulum (ER) of Madin-Darby canine...

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Share to Bartter Syndrome
Share to Chloride Channels

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knock-In Techniques

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Source

Identifiers

PMID: 21593186
DOI: 10.1152/ajprenal.00604.2010

Genes

BSND

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Generation and analyses of R8L barttin knockin mouse.PMID 21593186Read ↗

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Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III.Semantic proximity Read ↗

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