Article
Molecular mechanisms of Bartter syndrome caused by mutations in the BSND gene.
Histochemistry and cell biology - 1 Jun 2003
Hayama Atsushi, Rai Tatemitsu, Sasaki Sei, Uchida Shinichi
Abstract excerpt
Barttin, a gene product of BSND, was identified as a fourth gene responsible for Bartter syndrome. The co-expression of barttin with CLC-K chloride channels has been demonstrated to dramatically induce the expression of CLC-K current. However, it remains unknown how barttin interacts with CLC-K channels in mammalian cells and how the mutations of barttin lead to Bartter syndrome. In an attempt to clarify the...
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