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Article

Salt-losing nephropathy in mice with a null mutation of the Clcnk2 gene.

Acta physiologica (Oxford, England) - 1 Nov 2016

Grill A, Schießl I M, Gess B, Fremter K, Hammer A, Castrop H

Abstract excerpt

AIM: The basolateral chloride channel ClC-Kb facilitates Cl reabsorption in the distal nephron of the human kidney. Functional mutations in CLCNKB are associated with Bartter's syndrome type 3, a hereditary salt-losing nephropathy. To address the function of ClC-K2 in vivo, we generated ClC-K2-deficient mice. METHODS: ClC-K2-deficient mice were generated using TALEN technology. RESULTS: ClC-K2-deficient mice were...

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Source

Identifiers

PMID: 27421685
DOI: 10.1111/apha.12755

Genes

CLCNKB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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