Article
PTPN22 association in systemic lupus erythematosus (SLE) with respect to individual ancestry and clinical sub-phenotypes.
PloS one - 1 Jan 2013
Namjou Bahram, Kim-Howard Xana, Sun Celi, Adler Adam, Chung Sharon A, Kaufman Kenneth M, Kelly Jennifer A, Glenn Stuart B, Guthridge Joel M, Scofield Robert H, Kimberly Robert P, Brown Elizabeth E, Alarcón Graciela S, Edberg Jeffrey C, Kim Jae-Hoon, Choi Jiyoung, Ramsey-Goldman Rosalind, Petri Michelle A, Reveille John D, Vilá Luis M, Boackle Susan A, Freedman Barry I, Tsao Betty P, Langefeld Carl D, Vyse Timothy J, Jacob Chaim O, Pons-Estel Bernardo, Niewold Timothy B, Moser Sivils Kathy L, Merrill Joan T, Anaya Juan-Manuel, Gilkeson Gary S, Gaffney Patrick M, Bae Sang-Cheol, Alarcón-Riquelme Marta E, Harley John B, Criswell Lindsey A, James Judith A, Nath Swapan K
Abstract excerpt
Protein tyrosine phosphatase non-receptor type 22 (PTPN22) is a negative regulator of T-cell activation associated with several autoimmune diseases, including systemic lupus erythematosus (SLE). Missense rs2476601 is associated with SLE in individuals with European ancestry. Since the rs2476601 risk allele frequency differs dramatically across ethnicities, we assessed robustness of PTPN22 association with SLE and...
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