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Article

PTPN22 1858C>T (R620W) functional polymorphism and human longevity.

Molecular biology reports - 1 Aug 2011

Napolioni Valerio, Natali Annalia, Saccucci Patrizia, Lucarini Nazzareno

Abstract excerpt

The PTPN22 gene, located on chromosome 1p13, encoding lymphoid protein tyrosine phosphatase (LYP), plays a crucial role in the negative control of T lymphocyte activation. Since the age-related change in T-cell signal transduction may be one of the most important causes of cell-mediated immune re...

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Source

Identifiers

PMID: 21113673
DOI: 10.1007/s11033-010-0546-8

Genes

PTPN22

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21113673-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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