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Article

Integration is not necessary for expression of human immunodeficiency virus type 1 protein products.

Journal of virology - 1 May 1990

Stevenson M, Haggerty S, Lamonica C A, Meier C M, Welch S K, Wasiak A J

Abstract excerpt

A common feature in the life cycle of cytocidal retroviruses, including human immunodeficiency virus type 1 (HIV-1), is the accumulation of large amounts of unintegrated viral DNA. As yet, the role of unintegrated viral DNA in the cytopathogenesis of cytocidal retrovirus infections remains unresolved. HIV-1 mutants which were deleted in the integrase/endonuclease gene and which were unable to establish an...

Topics

CD4 Antigens
Cell Line
Chromosome Deletion
DNA Transposable Elements
DNA, Viral
Gene Expression
Genes, Viral
HIV-1
HeLa Cells
Humans
Lysogeny
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Transfection

Viral Proteins

Viral Structural Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 2157898
DOI: 10.1128/JVI.64.5.2421-2425.1990
PMCID: PMC249408

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2157898-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Integration is not necessary for expression of human immunodeficiency virus type 1 protein products.PMID 2157898Read ↗

The role of unintegrated DNA in HIV infectionSemantic proximity Read ↗

Integration is essential for efficient gene expression of human immunodeficiency virus type 1Semantic proximity Read ↗

Human immunodeficiency virus type 1 integrase: effects of mutations on viral ability to integrate, direct viral gene expression from unintegrated viral DNA templates, and sustain viral propagation in primary cells.Semantic proximity Read ↗

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Efficient Concerted Integration by Recombinant Human Immunodeficiency Virus Type 1 Integrase without Cellular or Viral CofactorsSemantic proximity Read ↗

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The Cell Cycle Independence of HIV Infections Is Not Determined by Known Karyophilic Viral ElementsSemantic proximity Read ↗

Self-limiting, cell type-dependent replication of an integrase-defective human immunodeficiency virus type 1 in human primary macrophages but not T lymphocytes.Semantic proximity Read ↗

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