Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integration is not necessary for expression of human immunodeficiency virus type 1 protein products.

Journal of virology - 1 May 1990

Stevenson M, Haggerty S, Lamonica C A, Meier C M, Welch S K, Wasiak A J

Abstract excerpt

A common feature in the life cycle of cytocidal retroviruses, including human immunodeficiency virus type 1 (HIV-1), is the accumulation of large amounts of unintegrated viral DNA. As yet, the role of unintegrated viral DNA in the cytopathogenesis of cytocidal retrovirus infections remains unresolved. HIV-1 mutants which were deleted in the integrase/endonuclease gene and which were unable to establish an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to Chromosome Deletion
Share to DNA Transposable Elements

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA, Viral

Share to Gene Expression

Share to Mutation

Share to Polymerase Chain Reaction

Share to Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 2157898
DOI: 10.1128/JVI.64.5.2421-2425.1990
PMCID: PMC249408

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integration is not necessary for expression of human immunodeficiency virus type 1 protein products.PMID 2157898Read ↗

The role of unintegrated DNA in HIV infectionSemantic proximity Read ↗

Integration is essential for efficient gene expression of human immunodeficiency virus type 1Semantic proximity Read ↗

Human immunodeficiency virus type 1 integrase: effects of mutations on viral ability to integrate, direct viral gene expression from unintegrated viral DNA templates, and sustain viral propagation in primary cells.Semantic proximity Read ↗

Human Immunodeficiency Virus Type 1 (HIV-1) Vpr Enhances Expression from Unintegrated HIV-1 DNASemantic proximity Read ↗

Human immunodeficiency virus type 1 replication in the absence of integrase-mediated dna recombination: definition of permissive and nonpermissive T-cell lines.Semantic proximity Read ↗

Simian virus 40-based replication of catalytically inactive human immunodeficiency virus type 1 integrase mutants in nonpermissive T cells and monocyte-derived macrophages.Semantic proximity Read ↗

Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication.Semantic proximity Read ↗

Efficient Concerted Integration by Recombinant Human Immunodeficiency Virus Type 1 Integrase without Cellular or Viral CofactorsSemantic proximity Read ↗

Evidence for Gene Expression by Unintegrated Human Immunodeficiency Virus Type 1 DNA SpeciesSemantic proximity Read ↗

Multiple integrase functions are required to form the native structure of the human immunodeficiency virus type I intasome.Semantic proximity Read ↗

The Cell Cycle Independence of HIV Infections Is Not Determined by Known Karyophilic Viral ElementsSemantic proximity Read ↗

Self-limiting, cell type-dependent replication of an integrase-defective human immunodeficiency virus type 1 in human primary macrophages but not T lymphocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.