Article
Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication.
Journal of virology - 1 May 1995
Engelman A, Englund G, Orenstein J M, Martin M A, Craigie R
Abstract excerpt
The integration of a DNA copy of the human immunodeficiency virus type 1 (HIV-1) genome into a chromosome of an infected cell is a pivotal step in virus replication. Integration requires the activity of the virus-encoded integrase, which enters the cell as a component of the virion. Results of nu...
Topics
- Base Sequence
- Cloning, Molecular
- DNA Nucleotidyltransferases
- DNA Primers
- DNA, Viral
- Defective Viruses
- Gene Expression
- Genes, pol
- HIV Reverse Transcriptase
- HIV-1
- HeLa Cells
- Humans
- Integrases
- Microscopy, Electron
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Point Mutation