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Article

Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication.

Journal of virology - 1 May 1995

Engelman A, Englund G, Orenstein J M, Martin M A, Craigie R

Abstract excerpt

The integration of a DNA copy of the human immunodeficiency virus type 1 (HIV-1) genome into a chromosome of an infected cell is a pivotal step in virus replication. Integration requires the activity of the virus-encoded integrase, which enters the cell as a component of the virion. Results of numerous mutagenesis studies have identified amino acid residues and protein domains of HIV-1 integrase critical for in...

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Identifiers

PMID: 7535863
DOI: 10.1128/JVI.69.5.2729-2736.1995
PMCID: PMC188965

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication.PMID 7535863Read ↗

Human immunodeficiency virus type 1 integrase: effects of mutations on viral ability to integrate, direct viral gene expression from unintegrated viral DNA templates, and sustain viral propagation in primary cells.Semantic proximity Read ↗

Multimodal Functionalities of HIV-1 IntegraseSemantic proximity Read ↗

Going beyond Integration: The Emerging Role of HIV-1 Integrase in Virion MorphogenesisSemantic proximity Read ↗

Genetic analysis of the human immunodeficiency virus type 1 integrase proteinSemantic proximity Read ↗

Human immunodeficiency virus type 1 integrase: effect on viral replication of mutations at highly conserved residuesSemantic proximity Read ↗

Human immunodeficiency virus type 1 integrase mutants retain in vitro integrase activity yet fail to integrate viral DNA efficiently during infectionSemantic proximity Read ↗

Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis.Semantic proximity Read ↗

Molecular mechanisms of HIV integration and therapeutic interventionSemantic proximity Read ↗

The Molecular Biology of HIV IntegraseSemantic proximity Read ↗

Genetic analysis of human immunodeficiency virus type 1 integrase and the U3 att site: unusual phenotype of mutants in the zinc finger-like domain.Semantic proximity Read ↗

Mutations in the catalytic core or the C-terminus of murine leukemia virus (MLV) integrase disrupt virion infectivity and exert diverse effects on reverse transcription.Semantic proximity Read ↗

Mutational scan of the human immunodeficiency virus type 2 integrase protein.Semantic proximity Read ↗

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