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Article

Integration is essential for efficient gene expression of human immunodeficiency virus type 1

1 Mar 1993

Abstract excerpt

A mutant of human immunodeficiency virus type 1 which carries a frameshift insertion in the integrase/endonuclease region of pol gene was constructed in vitro. Upon transfection into cells, although this mutant exhibited a normal phenotype with respect to expression of gag, pol, and env genes and to generation of progeny virions, no replication-competent virus in CD4-positive cells emerged. An assay for the...

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Identifiers

PMID: 8437208
DOI: 10.1128/jvi.67.3.1169-1174.1993

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