Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human immunodeficiency virus type 1 replication in the absence of integrase-mediated dna recombination: definition of permissive and nonpermissive T-cell lines.

Journal of virology - 1 Sept 2001

Nakajima N, Lu R, Engelman A

Abstract excerpt

Functional retroviral integrase protein is thought to be essential for productive viral replication. Yet, previous studies differed on the extent to which integrase mutant viruses expressed human immunodeficiency virus type 1 (HIV-1) genes from unintegrated DNA. Although one reason for this difference was that class II integrase mutations pleiotropically affected the viral life cycle, another reason apparently...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD4-Positive T-Lymphocytes
Share to Cell Line

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA, Viral

Share to HIV Integrase

Share to Mutation

Share to Recombination, Genetic

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 11483739
DOI: 10.1128/jvi.75.17.7944-7955.2001
PMCID: PMC115038

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human immunodeficiency virus type 1 replication in the absence of integrase-mediated dna recombination: definition of permissive and nonpermissive T-cell lines.PMID 11483739Read ↗

Simian virus 40-based replication of catalytically inactive human immunodeficiency virus type 1 integrase mutants in nonpermissive T cells and monocyte-derived macrophages.Semantic proximity Read ↗

Human immunodeficiency virus type 1 integrase: effects of mutations on viral ability to integrate, direct viral gene expression from unintegrated viral DNA templates, and sustain viral propagation in primary cells.Semantic proximity Read ↗

Integration is essential for efficient gene expression of human immunodeficiency virus type 1Semantic proximity Read ↗

Cell-free infectivity of HIV type 1 produced in nonpermissive cells is only moderately impacted by C-terminal Env truncation despite abrogation of viral spread.Semantic proximity Read ↗

Inhibition of HIV-1 virion production by a transdominant mutant of integrase interactor 1Semantic proximity Read ↗

Isolation and characterization of replication-competent human immunodeficiency virus type 1 from a subset of elite suppressors.Semantic proximity Read ↗

Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication.Semantic proximity Read ↗

Human immunodeficiency virus type 1 integrase: effect on viral replication of mutations at highly conserved residuesSemantic proximity Read ↗

Efficiency of Human Immunodeficiency Virus Type 1 Postentry Infection Processes: Evidence against Disproportionate Numbers of Defective VirionsSemantic proximity Read ↗

Multimodal Functionalities of HIV-1 IntegraseSemantic proximity Read ↗

Human Immunodeficiency Virus Env-Independent Infection of Human CD4 − CellsSemantic proximity Read ↗

Comparative analyses of human immunodeficiency virus type 1 (HIV-1) and HIV-2 Vif mutants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.