Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A nonsynonymous polymorphism of IRAK4 associated with increased prevalence of gram-positive infection and decreased response to toll-like receptor ligands.

Journal of innate immunity - 1 Jan 2011

Sutherland Ainsley M, Walley Keith R, Nakada Taka-Aki, Sham Andy H P, Wurfel Mark M, Russell James A

Abstract excerpt

Mutations in IRAK4 have been associated with recurrent Gram-positive infections in children. Given the central role of IRAK4 in innate immunity signaling, we hypothesized that common genetic variants of IRAK4 may be associated with prevalence of Gram-positive infection in critically ill adults. Haplotype clade tag single nucleotide polymorphisms (SNPs) of the IRAK4 gene were selected and genotyped in a cohort of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gram-Positive Bacterial Infections
Share to Immunity, Innate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunization

Share to Interleukin-1 Receptor-Associated Kinases

Share to Interleukin-6

Share to Systemic Inflammatory Response Syndrome

Share to Toll-Like Receptors

Share to Transgenes

Source

Open in PubMed Open full text

Identifiers

PMID: 21576904
DOI: 10.1159/000323880
PMCID: PMC3186712

Genes

IRAK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A nonsynonymous polymorphism of IRAK4 associated with increased prevalence of gram-positive infection and decreased response to toll-like receptor ligands.PMID 21576904Read ↗

Excess of rare amino acid polymorphisms in the Toll-like receptor 4 in humans.Semantic proximity Read ↗

Clinical IRAK4 deficiency caused by homozygosity for the novel IRAK4 (c.1049delG, p.Gly350Glufs*15) variant.Semantic proximity Read ↗

IRAK1 functional genetic variant affects severity of septic shock.Semantic proximity Read ↗

Genetic variation in Toll-like receptor signalling and the risk of inflammatory and immune diseases.Semantic proximity Read ↗

Polymorphisms in Toll-like receptor 4 and the systemic inflammatory response syndrome.Semantic proximity Read ↗

Mutations in TLR4 signaling that lead to increased susceptibility to infection in humans: an overview.Semantic proximity Read ↗

Genetic polymorphisms of innate and adaptive immunity as predictors of outcome in critically ill patients.Semantic proximity Read ↗

Interleukin-1 receptor-associated kinase 3 gene associates with susceptibility to acute lung injury.Semantic proximity Read ↗

Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts.Semantic proximity Read ↗

Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock.Semantic proximity Read ↗

Polymorphisms in CD14, mannose-binding lectin, and Toll-like receptor-2 are associated with increased prevalence of infection in critically ill adults.Semantic proximity Read ↗

A coding IRAK2 protein variant compromises Toll-like receptor (TLR) signaling and is associated with colorectal cancer survival.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.