Article
A coding IRAK2 protein variant compromises Toll-like receptor (TLR) signaling and is associated with colorectal cancer survival.
The Journal of biological chemistry - 15 Aug 2014
Wang Hui, Flannery Sinead M, Dickhöfer Sabine, Huhn Stefanie, George Julie, Kubarenko Andriy V, Lascorz Jesus, Bevier Melanie, Willemsen Joschka, Pichulik Tica, Schafmayer Clemens, Binder Marco, Manoury Bénédicte, Paludan Søren R, Alarcon-Riquelme Marta, Bowie Andrew G, Försti Asta, Weber Alexander N R
Abstract excerpt
Within innate immune signaling pathways, interleukin-1 receptor-associated kinases (IRAKs) fulfill key roles downstream of multiple Toll-like receptors and the interleukin-1 receptor. Although human IRAK4 deficiency was shown to lead to severe immunodeficiency in response to pyogenic bacterial infection during childhood, little is known about the role of human IRAK2. We here identified a non-synonymous IRAK2...
Topics
- Amino Acid Substitution
- Animals
- Biomarkers, Tumor
- Colorectal Neoplasms
- HEK293 Cells
- Humans
- Interleukin-1 Receptor-Associated Kinases
- Mice
- Mice, Knockout