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Article

The relative efficiency of homology-directed repair has distinct effects on proper anaphase chromosome separation.

Nucleic acids research - 1 Aug 2011

Laulier Corentin, Cheng Anita, Stark Jeremy M

Abstract excerpt

Homology-directed repair (HDR) is essential to limit mutagenesis, chromosomal instability (CIN) and tumorigenesis. We have characterized the consequences of HDR deficiency on anaphase, using markers for incomplete chromosome separation: DAPI-bridges and Ultra-fine bridges (UFBs). We show that multiple HDR factors (Rad51, Brca2 and Brca1) are critical for complete chromosome separation during anaphase, while...

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Identifiers

PMID: 21459848
DOI: 10.1093/nar/gkr187
PMCID: PMC3152340

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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