Article
Kappa light chain gene rearrangement in T-cell acute lymphoblastic leukemia.
American journal of clinical pathology - 1 Apr 1990
Hanson C A, Thamilarasan M, Ross C W, Stoolman L M, Schnitzer B
Abstract excerpt
Immunoglobulin and T-cell receptor gene rearrangement assays are sensitive methods of detecting clonality in lymphoproliferative disorders. The lack of lineage specificity of immunoglobulin heavy chain and T-cell receptor beta and gamma gene probes in acute leukemia is well established. However, immunoglobulin light chain gene rearrangement traditionally has been considered a highly specific indicator of a clonal...
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