Article
T cell receptor and immunoglobulin gene rearrangement analysis as a laboratory aid in the diagnosis of human malignant lymphoproliferative diseases.
Australian and New Zealand journal of medicine - 1 Jun 1991
Dietzsch E, Hong J, Leslie D E, Martin L, Rolland J, Benson E, Toh B H, McCluskey J
Abstract excerpt
The identification of clonal rearrangements of the immunoglobulin heavy chain and T cell receptor beta chain gene loci by Southern blot analysis has led to advances in the diagnosis and classification of lymphoproliferative disorders. This paper reviews our experience with this technique over a t...
Topics
- Gene Rearrangement
- Gene Rearrangement, T-Lymphocyte
- Genes, Immunoglobulin
- Genotype
- Humans
- Immunoglobulin Heavy Chains
- Immunophenotyping
- Lymphoproliferative Disorders
- Retrospective Studies
- Sensitivity and Specificity