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Article

Characterization of immunoglobulin and T-cell receptor gene patterns in B-cell precursor acute lymphoblastic leukemia of childhood.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Mar 1990

Felix C A, Poplack D G, Reaman G H, Steinberg S M, Cole D E, Taylor B J, Begley C G, Kirsch I R

Abstract excerpt

Immunoglobulin (Ig) and T-cell receptor (TCR) genes were examined in the lymphoblasts of 70 children with immunophenotypically defined B-cell precursor acute lymphoblastic leukemia (ALL). The most frequent genes to rearrange were Ig heavy (H) chain (93%) and TCR delta (79%), followed by TCR gamma (49%), Ig kappa and/or lambda light (L) chain (46%), TCR alpha (46%), and TCR beta (29%). Thus, despite their putative...

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Identifiers

PMID: 2307988
DOI: 10.1200/JCO.1990.8.3.431

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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