Characterization of immunoglobulin and T-cell receptor gene patterns in B-cell precursor acute lymphoblastic leukemia of childhood.

doi:10.1200/JCO.1990.8.3.431

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Article

Characterization of immunoglobulin and T-cell receptor gene patterns in B-cell precursor acute lymphoblastic leukemia of childhood.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Mar 1990

Felix C A, Poplack D G, Reaman G H, Steinberg S M, Cole D E, Taylor B J, Begley C G, Kirsch I R

Abstract excerpt

Immunoglobulin (Ig) and T-cell receptor (TCR) genes were examined in the lymphoblasts of 70 children with immunophenotypically defined B-cell precursor acute lymphoblastic leukemia (ALL). The most frequent genes to rearrange were Ig heavy (H) chain (93%) and TCR delta (79%), followed by TCR gamma...

Topics

Adolescent
Adult
Child
Child, Preschool
Gene Rearrangement, T-Lymphocyte
Genotype
Humans
Infant
Phenotype
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Receptors, Antigen, T-Cell
Receptors, Immunologic
Retrospective Studies

Source

Open in PubMed

Identifiers

PMID: 2307988
DOI: 10.1200/JCO.1990.8.3.431

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2307988-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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