Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA Methyltransferase Controls Stem Cell Aging by Regulating BMI1 and EZH2 through MicroRNAs

10 May 2011

Abstract excerpt

Epigenetic regulation of gene expression is well known mechanism that regulates cellular senescence of cancer cells. Here we show that inhibition of DNA methyltransferases (DNMTs) with 5-azacytidine (5-AzaC) or with specific small interfering RNA (siRNA) against DNMT1 and 3b induced the cellular senescence of human umbilical cord blood-derived multipotent stem cells (hUCB-MSCs) and increased p16(INK4A) and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Epigenetics and DNA Methylation
Share to MicroRNA in disease regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21572997
DOI: 10.1371/journal.pone.0019503

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA Methyltransferase Controls Stem Cell Aging by Regulating BMI1 and EZH2 through MicroRNAsPMID 21572997Read ↗

Histone deacetylase controls adult stem cell aging by balancing the expression of polycomb genes and jumonji domain containing 3Semantic proximity Read ↗

Epigenetic regulation of mesenchymal stem cell aging through histone modificationsSemantic proximity Read ↗

Dysregulated transcriptional and post-translational control of DNA methyltransferases in cancerSemantic proximity Read ↗

p21Waf1/Cip1 plays a critical role in modulating senescence through changes of DNA methylationSemantic proximity Read ↗

The Ubiquitin-like with PHD and Ring Finger Domains 1 (UHRF1)/DNA Methyltransferase 1 (DNMT1) Axis Is a Primary Regulator of Cell Senescence.Semantic proximity Read ↗

DNA methylation in stem cell renewal and multipotencySemantic proximity Read ↗

Bmi1, stem cells, and senescence regulation.Semantic proximity Read ↗

miRNAs regulate stem cell self-renewal and differentiationSemantic proximity Read ↗

microRNA-141 regulates BMI1 expression and induces senescence in human diploid fibroblastsSemantic proximity Read ↗

Role of the polycomb group gene BMI1 in normal and leukemic hematopoietic stem and progenitor cells.Semantic proximity Read ↗

Cellular senescence mediated by p16INK4A-coupled miRNA pathwaysSemantic proximity Read ↗

Ink4a/Arf Regulation by let-7b and Hmga2: A Genetic Pathway Governing Stem Cell AgingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.