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Article

Epigenetic regulation of mesenchymal stem cell aging through histone modifications

5 Dec 2022

Abstract excerpt

Stem cell senescence and exhaustion, a hallmark of aging, lead to declines in tissue repair and regeneration in aged individuals. Emerging evidence has revealed that epigenetic regulation plays critical roles in the self-renew, lineage-commitment, survival, and function of stem cells. Moreover, epigenetic alterations are considered important drivers of stem cell dysfunction during aging. In this review, we...

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PMID: 37554203
DOI: 10.1016/j.gendis.2022.10.030

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