Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p21Waf1/Cip1 plays a critical role in modulating senescence through changes of DNA methylation

2 Mar 2006

Abstract excerpt

It has been reported that genomic DNA methylation decreases gradually during cell culture and an organism's aging. However, less is known about the methylation changes of age-related specific genes in aging. p21(Waf1/Cip1) and p16(INK4a) are cyclin-dependent kinase (Cdk) inhibitors that are critical for the replicative senescence of normal cells. In this study, we show that p21(Waf1/Cip1) and p16(INK4a) have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Genetics and Neurodevelopmental Disorders
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16514663
DOI: 10.1002/jcb.20838

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p21Waf1/Cip1 plays a critical role in modulating senescence through changes of DNA methylationPMID 16514663Read ↗

Differential Roles for Cyclin-Dependent Kinase Inhibitors p21 and p16 in the Mechanisms of Senescence and Differentiation in Human FibroblastsSemantic proximity Read ↗

DNA Methyltransferase Controls Stem Cell Aging by Regulating BMI1 and EZH2 through MicroRNAsSemantic proximity Read ↗

Effects of p21 <sup>Waf1/Cip1/Sdi1</sup> on cellular gene expression: Implications for carcinogenesis, senescence, and age-related diseasesSemantic proximity Read ↗

RASSF1A Mediates p21Cip1/Waf1-Dependent Cell Cycle Arrest and Senescence through Modulation of the Raf-MEK-ERK Pathway and Inhibition of AktSemantic proximity Read ↗

New insights into p53 signaling and cancer cell response to DNA damage: implications for cancer therapy.Semantic proximity Read ↗

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblastsSemantic proximity Read ↗

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblastsSemantic proximity Read ↗

CREG1 enhances p16 INK4a -induced cellular senescenceSemantic proximity Read ↗

Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1.Semantic proximity Read ↗

Transcriptional regulation of CDKN2A/p16 by sirtuin 7 in senescenceSemantic proximity Read ↗

The molecular balancing act of p16(INK4a) in cancer and aging.Semantic proximity Read ↗

Regulation of p53 during senescence in normal human keratinocytesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.