Article

Increased baseline RASGRP1 signals Enhance Stem Cell Fitness during Native Hematopoiesis

2020-06-25

Abstract excerpt

Oncogenic mutations in RAS genes, like KRAS G12D or NRAS G12D , trap Ras in the active state and cause myeloproliferative disorder and T cell leukemia (T-ALL) when induced in the bone marrow via Mx1CRE . The RAS exchange factor RASGRP1 is frequently overexpressed in T-ALL patients. In T-ALL cell lines overexpression of RASGRP1 increases flux through the RASGTP/RasGDP cycle. Here we expanded RASGRP1 expressi...

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Literature Corpus work: acfa6423-326b-57f5-9d62-ff37129670f9
DOI: 10.1101/2020.06.24.169631

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