Article
Disease fingerprinting with cDNA microarrays reveals distinct gene expression profiles in lethal type 1 and type 2 cytokine-mediated inflammatory reactions.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 2001
Hoffmann K F, McCarty T C, Segal D H, Chiaramonte M, Hesse M, Davis E M, Cheever A W, Meltzer P S, Morse H C, Wynn T A
Abstract excerpt
Development of polarized immune responses controls resistance and susceptibility to many microorganisms. However, studies of several infectious, allergic, and autoimmune diseases have shown that chronic type-1 and type-2 cytokine responses can also cause significant morbidity and mortality if left unchecked. We used mouse cDNA microarrays to molecularly phenotype the gene expression patterns that characterize two...
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