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Multicolor lineage tracing reveals clonal architecture and dynamics in colon cancer

6 Nov 2017

Abstract excerpt

Colon cancers are composed of phenotypically heterogeneous tumor cell subpopulations with variable expression of putative stem cell and differentiation antigens. While in normal colonic mucosa, clonal repopulation occurs along differentiation gradients from crypt base toward crypt apex, the clonal architecture of colon cancer and the relevance of tumor cell subpopulations for clonal outgrowth are poorly...

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PMID: 29127276
DOI: 10.1038/s41467-017-00976-9

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