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Comparative functional genomics for identifying models of human cancer

27 Jan 2005

Abstract excerpt

Genetically modified mice with overexpressed and/or deleted genes have been used extensively to model human cancer. However, it is uncertain as to what extent the mouse models reproduce the corresponding cancers in humans. We have compared the global gene expression patterns in human and mouse hepatocellular carcinomas (HCCs) in an attempt to identify the mouse models that most extensively reproduce the molecular...

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PMID: 15677630
DOI: 10.1093/carcin/bgi030

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