Article
Is current serologic RhD typing of blood donors sufficient for avoiding immunization of recipients?
Transfusion - 1 Nov 2011
Krog Grethe Risum, Clausen Frederik Banch, Berkowicz Adela, Jørgensen Lone, Rieneck Klaus, Nielsen Leif Kofoed, Dziegiel Morten Hanefeld
Abstract excerpt
BACKGROUND: Avoiding immunization with clinically important antibodies is a primary objective in transfusion medicine. Therefore, it is central to identify the extent of D antigens that escape routine RhD typing of blood donors and to improve methodology if necessary. STUDY DESIGN AND METHODS: We screened 5058 D- donors for the presence of the RHD gene, targeting Exons 5, 7, and 10 with real-time polymerase chain...
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