Article
RHD-negative red cells may be avoided for patients with ambiguous serologic typing for the RHD antigen.
Transfusion - 1 Feb 2024
Juhl David, Luckner Kathrin, Brockmann Christian, Musiolik Ingrid, Bunge-Philipowski Tina, Görg Siegfried, Ziemann Malte
Abstract excerpt
BACKGROUND AND OBJECTIVES: Serologic typing with monoclonal anti-D is mandatory for RHD antigen determination before transfusion, but due to aberrant (weak or partial) variants of RHD, results may be ambiguous and molecular RHD-typing is required. Before that, RHD-negative (RHD -) red blood cells concentrates (RBCs) shall be transfused to avoid anti-D formation, which probably leads to wastage of RHD - RBCs....
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