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Article

Transitioning a multiethnic donor pool from serologic D-negative to molecularly RHD-negative at a hospital-based blood donor service.

Journal of translational medicine - 19 Jun 2025

Flegel Willy A, Srivastava Kshitij, Caruccio Lorraine G, Schmid Pirmin, Stiles David A, Bueno Marina U, Dowling Nadine R, Paige Traci D, Shrestha Sita

Abstract excerpt

BACKGROUND: Some individuals carry a very low expression of the D-antigen, called a Del phenotype. Red cell units from such blood donors with DEL alleles are RhD protein-positive, despite being routinely labelled D-negative. Molecular typing offers a more sensitive method to identify Del individuals by detecting the presence of the RHD gene. Pools of 20 or more donor samples are routinely screened for the RHD...

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Identifiers

PMID: 40537781
DOI: 10.1186/s12967-025-06716-8
PMCID: PMC12180192

Genes

RHD

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transitioning a multiethnic donor pool from serologic D-negative to molecularly RHD-negative at a hospital-based blood donor service.PMID 40537781Read ↗

Clinical and laboratory update on the DEL variant.Semantic proximity Read ↗

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