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Article

TRAF2 and p38 are involved in B cells CD40-mediated APE/Ref-1 nuclear translocation: a novel pathway in B cell activation.

Molecular immunology - 1 Jan 2008

Merluzzi Sonia, D'Orlando Orietta, Leonardi Antonio, Vitale Gaetano, Pucillo Carlo

Abstract excerpt

The interaction between CD40 and its ligand CD40L plays a key role in the regulation of B cell proliferation, activation, isotype switching and the humoral memory response. APE/Ref-1 plays a key role in transcriptional responses during CD40-mediated B cell activation. It is demonstrated that CD40 signaling is mediated principally through TRAF adapter proteins. Different TRAFs exhibit specific biological functions...

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Source

Identifiers

PMID: 17599408
DOI: 10.1016/j.molimm.2007.05.010

Genes

TRAF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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