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Article

Functions of CD40 and Its Ligand, gp39 (CD40L)

1 Jan 2017

Abstract excerpt

Initially, a role for the interaction between CD40, expressed on B cells, and gp39 (CD40L), expressed on activated T cells, has been defined in humoral immunity. CD40-CD40L interaction is an essential signal for B cell proliferation, expression of activation markers, immunoglobulin production, and isotype switching. CD40-CD40L interaction is also required for formation of B memory cells and germinal centers, and...

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PMID: 29773027
DOI: 10.1615/critrevimmunol.v37.i2-6.100

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