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Article

Segregation of recombined chromosomes in meiosis I requires DNA topoisomerase II.

Cell - 23 Mar 1990

Rose D, Thomas W, Holm C

Abstract excerpt

To understand better the similarities and differences between meiosis and mitosis, we examined the meiotic role of DNA topoisomerase II, an enzyme that is required mitotically to disentangle sister chromatids at the time of chromosome segregation. In meiosis, we found that topoisomerase II is required only at the time of nuclear division. When cold-sensitive top2 mutants are induced to sporulate at the...

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Identifiers

PMID: 2156624
DOI: 10.1016/0092-8674(90)90349-j

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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