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Article

Hydrophobic core evolution of major histocompatibility complex class I chain-related protein A for dramatic enhancing binding affinity.

International journal of biological macromolecules - 1 Jun 2024

Cai Wenxuan, Peng Siqi, Tian Ye, Bao Yifeng, Liu Qiang, Dong Yan, Liang Zhaoduan, Liu Qi, Ren Yuefei, Ding Peng, Liu Jinsong, Xu Tingting, Li Yi

Abstract excerpt

Interface residues at sites of protein-protein interaction (PPI) are the focus for affinity optimisation. However, protein hydrophobic cores (HCs) play critical roles and shape the protein surface. We hypothesise that manipulating protein HCs can enhance PPI interaction affinities. A cell stress molecule, major histocompatibility complex class I chain-related protein A (MICA), binds to the natural killer group 2D...

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Share to Histocompatibility Antigens Class I
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38788878
DOI: 10.1016/j.ijbiomac.2024.132588

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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