Article
Design of an HA2-based Escherichia coli expressed influenza immunogen that protects mice from pathogenic challenge.
Proceedings of the National Academy of Sciences of the United States of America - 3 Aug 2010
Bommakanti Gayathri, Citron Michael P, Hepler Robert W, Callahan Cheryl, Heidecker Gwendolyn J, Najar Tariq Ahmad, Lu Xianghan, Joyce Joseph G, Shiver John W, Casimiro Danilo R, ter Meulen Jan, Liang Xiaoping, Varadarajan Raghavan
Abstract excerpt
Influenza HA is the primary target of neutralizing antibodies during infection, and its sequence undergoes genetic drift and shift in response to immune pressure. The receptor binding HA1 subunit of HA shows much higher sequence variability relative to the metastable, fusion-active HA2 subunit, presumably because neutralizing antibodies are primarily targeted against the former in natural infection. We have...
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