Article
The nucleolar GTP-binding proteins Gnl2 and nucleostemin are required for retinal neurogenesis in developing zebrafish.
Developmental biology - 15 Jul 2011
Paridaen Judith T M L, Janson Esther, Utami Kagistia Hana, Pereboom Tamara C, Essers Paul B, van Rooijen Carina, Zivkovic Danica, MacInnes Alyson W
Abstract excerpt
Nucleostemin (NS), a member of a family of nucleolar GTP-binding proteins, is highly expressed in proliferating cells such as stem and cancer cells and is involved in the control of cell cycle progression. Both depletion and overexpression of NS result in stabilization of the tumor suppressor p53 protein in vitro. Although it has been previously suggested that NS has p53-independent functions, these to date...
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