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Article

Drosophila GTPase nucleostemin 2 changes cellular distribution during larval development and the GTP-binding motif is essential to nucleoplasmic localization.

Bioscience, biotechnology, and biochemistry - 1 Jan 2011

Matsuo Eriko, Nagamine Toshihiro, Matsumoto Shogo, Tsuneizumi Kazuhide

Abstract excerpt

Nucleostemin (NS), a nucleolar guanosine triphosphate (GTP)-binding protein, plays significant roles in cell cycle progression and ribosomal biogenesis. Drosophila Nucleostemin 2 (NS2), a member of the Drosophila NS family, regulates early eye development and is essential to cell survival in vivo, but the underlying mechanisms have yet to be clarified. Biochemical analysis using the recombinant NS2 protein...

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PMID: 21821926
DOI: 10.1271/bbb.110212

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