Article
Regulation of ribosome biogenesis by nucleostemin 3 promotes local and systemic growth in Drosophila.
Genetics - 1 May 2013
Hartl Tom A, Ni Julie, Cao Jian, Suyama Kaye L, Patchett Stephanie, Bussiere Cyril, Gui Dan Yi, Tang Sheng, Kaplan Daniel D, Fish Matthew, Johnson Arlen W, Scott Matthew P
Abstract excerpt
Nucleostemin 3 (NS3) is an evolutionarily conserved protein with profound roles in cell growth and viability. Here we analyze cell-autonomous and non-cell-autonomous growth control roles of NS3 in Drosophila and demonstrate its GTPase activity using genetic and biochemical assays. Two null alleles of ns3, and RNAi, demonstrate the necessity of NS3 for cell autonomous growth. A hypomorphic allele highlights the...
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