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Article

Phenotypic properties of herpesvirus-transformed cells with high tumorigenic and metastatic ability.

Virus research - 1 Jan 1990

Marks G, Choudhury T, Howett M K

Abstract excerpt

Herpes simplex virus type 2-transformed hamster embryo fibroblasts (333-8-9 cells) produce increased plasminogen activator (PA) compared with normal hamster cells. These cells produce undifferentiated fibrosarcomas at the inoculation site in newborn hamsters, and metastasize to the lungs. Using a direct PA assay, in which 125I-labeled plasminogen is cleaved, the optimum pH and osmolarity for detection of the...

Topics

Animals
Cell Line, Transformed
Cell Transformation, Neoplastic
Cell Transformation, Viral
Cricetinae
Fibrosarcoma
Hydrogen-Ion Concentration
Molecular Weight
Osmolar Concentration
Phenotype
Plasminogen Activators

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Simplexvirus

Source

Identifiers

PMID: 2156388
DOI: 10.1016/0168-1702(90)90011-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2156388-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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