Enhanced production of tissue-type plasminogen activator by estradiol in a novel type variant of human breast cancer MCF-7 cell line.

doi:10.1016/0167-4889(90)90158-a

Back to search

Article

Enhanced production of tissue-type plasminogen activator by estradiol in a novel type variant of human breast cancer MCF-7 cell line.

Biochimica et biophysica acta - 22 May 1990

Mizoguchi H, Uchiumi T, Ono M, Kohno K, Kuwano M

Abstract excerpt

ES-1 cells, which showed a higher sensitivity to the cytocidal action of estradiol were isolated from a human breast cancer MCF-7 cell line. Growth of ES-1 cells was inhibited by a dose of 17-beta estradiol that stimulated the growth of the parental MCF-7 cells. Proteins secreted from MCF-7 and E...

Topics

Breast Neoplasms
Estradiol
Genetic Variation
Humans
Kinetics
RNA, Messenger
Tissue Plasminogen Activator
Tumor Cells, Cultured

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.