Article
Frequent genetic abnormalities of the PI3K/AKT pathway in primary ovarian cancer predict patient outcome.
Genes, chromosomes & cancer - 1 Aug 2011
Huang Jia, Zhang Lin, Greshock Joel, Colligon Theresa A, Wang Yan, Ward Renee, Katsaros Dionyssios, Lassus Heini, Butzow Ralf, Godwin Andrew K, Testa Joseph R, Nathanson Katherine L, Gimotty Phyllis A, Coukos George, Weber Barbara L, Degenhardt Yan
Abstract excerpt
Identification and characterization of underlying genetic aberrations could facilitate diagnosis and treatment of ovarian cancer. Copy number analysis using array Comparative Genomic Hybridization (aCGH) on 93 primary ovarian tumors identified PI3K/AKT pathway as the most frequently altered cancer related pathway. Furthermore, survival analyses to correlate gene copy number and mutation data with patient outcome...
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