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Article

Genomic Complexity and AKT Dependence in Serous Ovarian Cancer

3 Nov 2011

Abstract excerpt

UNLABELLED: Effective oncoprotein-targeted therapies have not yet been developed for ovarian cancer. To explore the role of PI3 kinase/AKT signaling in this disease, we performed a genetic and functional analysis of ovarian cancer cell lines and tumors. PI3K pathway alterations were common in both, but the spectrum of mutational changes differed. Genetic activation of the pathway was necessary, but not...

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PMID: 22328975
DOI: 10.1158/2159-8290.cd-11-0170

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