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Article

The association of PI3 kinase signaling and chemoresistance in advanced ovarian cancer.

Molecular cancer therapeutics - 1 Jul 2012

Carden Craig P, Stewart Adam, Thavasu Parames, Kipps Emma, Pope Lorna, Crespo Mateus, Miranda Susana, Attard Gerhardt, Garrett Michelle D, Clarke Paul A, Workman Paul, de Bono Johann S, Gore Martin, Kaye Stan B, Banerji Udai

Abstract excerpt

Evidence that the phosphoinositide 3-kinase (PI3K) pathway is deregulated in ovarian cancer is largely based on the analysis of surgical specimens sampled at diagnosis and may not reflect the biology of advanced ovarian cancer. We aimed to investigate PI3K signaling in cancer cells isolated from patients with advanced ovarian cancer. Ascites samples were analyzed from 88 patients, of whom 61 received further...

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Share to Class I Phosphatidylinositol 3-Kinases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-akt

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Source

Open in PubMed Open full text

Identifiers

PMID: 22556379
DOI: 10.1158/1535-7163.MCT-11-0996
PMCID: PMC4630857

Genes

PTEN
AKT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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