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Article

Sequence mutations and amplification of PIK3CA and AKT2 genes in purified ovarian serous neoplasms.

Cancer biology & therapy - 1 Jul 2006

Nakayama Kentaro, Nakayama Naomi, Kurman Robert J, Cope Leslie, Pohl Gudrun, Samuels Yardena, Velculescu Victor E, Wang Tian-Li, Shih Ie-Ming

Abstract excerpt

Sequence mutations and gene amplifications lead to activation of the PIK3CA-AKT2 signaling pathway and have been reported in several types of neoplasms including ovarian cancer. Analysis of such genetic alterations, however, is usually complicated by contamination of normal cell DNA, artifacts associated with formalin-fixed tissues and the sensitivity of the techniques employed. In this study, we analyzed the...

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Source

Identifiers

PMID: 16721043
DOI: 10.4161/cbt.5.7.2751

Genes

AKT2
BRAF
ERBB2
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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