Article
The role of genetic abnormalities of PTEN and the phosphatidylinositol 3-kinase pathway in breast and ovarian tumorigenesis, prognosis, and therapy.
Seminars in oncology - 1 Oct 2001
Mills G B, Lu Y, Fang X, Wang H, Eder A, Mao M, Swaby R, Cheng K W, Stokoe D, Siminovitch K, Jaffe R, Gray J
Abstract excerpt
Breast and ovarian cancers exhibit similar epidemiologic, genotypic, and phenotypic characteristics. Phosphatidylinositol 3-kinase (PI3K) and the PTEN tumor suppressor gene product phosphorylate and dephosphorylate the same 3' site in the inositol ring of membrane phosphatidylinositols. Germ-line mutations in the PTEN tumor suppressor gene are causative of Cowden's breast cancer predisposition syndrome, and PTEN...
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