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Article

HLA and insulin-dependent diabetes. A protective perspective.

Diabetes - 1 Feb 1992

Sheehy M J

Abstract excerpt

This article presents a model for the HLA effect in insulin-dependent diabetes mellitus (IDDM) that is almost the mirror image of a model suggested by Nepom. In the Nepom model, the products of certain HLA alleles are associated with IDDM because they bind and present a specific peptide or peptides so as to induce an immune response to pancreatic beta-cells; certain other alleles can protect against IDDM if they...

Topics

Alleles
Diabetes Mellitus, Type 1
Disease Susceptibility
HLA-D Antigens
Haplotypes
Humans
Models, Genetic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1733800
DOI: 10.2337/diab.41.2.123

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1733800-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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