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Article

N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans.

Nature - 12 May 2011

Lucanic Mark, Held Jason M, Vantipalli Maithili C, Klang Ida M, Graham Jill B, Gibson Bradford W, Lithgow Gordon J, Gill Matthew S

Abstract excerpt

Dietary restriction is a robust means of extending adult lifespan and postponing age-related disease in many species, including yeast, nematode worms, flies and rodents. Studies of the genetic requirements for lifespan extension by dietary restriction in the nematode Caenorhabditis elegans have implicated a number of key molecules in this process, including the nutrient-sensing target of rapamycin (TOR) pathway...

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PMID: 21562563
DOI: 10.1038/nature10007
PMCID: PMC3093655

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